Poise 2 Trial, It is an offence to reproduce or use the The POISE-2 Trial is a large international study to test if ASA and Clonidine can prevent heart attacks and deaths from heart problems around the time of surgery. placebo (n = 5,012). This placebo-controlled trial assessed The overall primary outcome of the POISE-2 Trial is a composite of all-cause mortality and nonfatal MI at 30 days after randomization. The trial looked at the efficacy and safety of low-dose clonidine vs. placebo and low-dose clonidine vs. In a meta-analysis of data from large, randomized trials involving more than 110,000 patients who were not undergoing surgery, the use of aspirin was shown to prevent myocardial infarction and major vascul Using a 2-by-2 factorial trial design, 10,010 non-cardiac surgery patients at risk of perioperative cardiovascular events were randomised to low-dose aspirin or POISE-2 was a randomized trial of perioperative aspirin and clonidine among patients undergoing noncardiac surgery. placebo in 10,000 patients at risk for a perioperative The POISE-2 trial was an investigator-initiated, global, multicentre, 2 × 2 factorial RCT of low-dose aspirin versus placebo and low-dose clonidine versus placebo in patients at risk of a . placebo and also POISE-2 Trial design: Patients undergoing noncardiac surgery were randomized to perioperative aspirin (n = 4,998) vs. A secondary outcome includes the composite of all-cause mortality, Methods: Using a 2-by-2 factorial trial design, we randomly assigned 10,010 patients who were preparing to undergo noncardiac surgery and were at risk for vascular complications to receive The objective of the POISE-2 study was to determine the impact of clonidine versus placebo and ASA versus placebo on the 30-day risk of all-cause mortality or We initiated the POISE-2 trial to determine the impact of low-dose ASA and low-dose clonidine on the 30-day risk of mortality and nonfatal myocardial infarction in patients having Prior to this study, practice regarding the use of perioperative aspirin was inconsistent. 2 mg ICH GCP EU Clinical Trials Registry Clinical Trial Page ICH GCP EU Clinical Trials Registry Clinical Trial Page The 2014 Perioperative Ischemic Evaluation 2, aspirin arm (POISE-2 ASA) trial randomized 10,010 patients at elevated risk for CV events undergoing non-cardiac surgery to ASA or POISE-2: A large, international, placebo-controlled, factorial trial to assess the impact of clonidine and aspirin in patients undergoing noncardiac surgery who are at risk of a perioperative cardiova The POISE-2 trial showed that perioperative use of aspirin in patients undergoing non-cardiac surgery increased the risk of major bleeding and did not decrease Patients in the POISE-2 trial were randomly assigned to one of four groups: ASA and Clonidine together ASA and Clonidine placebo ASA placebo and Clonidine POISE-2, conducted at 135 centers in 35 countries, randomized 10,010 patients undergoing noncardiac surgery to perioperative aspirin or The POISE-2 trial is a factorial design (low-dose acetylsalicylic acid [ASA] v. We have completed the POISE Abstract Background: We assessed associations between intraoperative neuraxial block and postoperative epidural analgesia, and a composite primary outcome of death or non-fatal The POISE-2 trial is a 2 × 2 factorial randomized controlled trial of low-dose ASA vs. The POISE-2 Pilot Trial will provide the essential remaining feasibility data that POISE-2 researchers require prior to conducting a large international study to test the effect of ASA and Version Date: March 1, 2010 This protocol has been developed by the POISE-2 Steering Committee and its contents are the intellectual property of this group. placebo and low-dose clonidine v. Full description POISE-2 is the largest clinical trial focused on major cardiovascular complications in non-cardiac surgery. placebo) that builds on the findings of POISE. POISE-2 is a multicentre, international, The Perioperative Ischemic Evaluation (POISE) 2 randomized control trial evaluated the perioperative antiplatelet drug management in noncardiac surgery. It found no benefit of aspirin or The 2014 Perioperative Ischemic Evaluation 2, aspirin arm (POISE-2 ASA) trial randomized 10,010 patients at elevated risk for CV events undergoing non-cardiac surgery to ASA or The POISE-2 Trial is a large international study to test if ASA and Clonidine can prevent heart attacks and deaths from heart problems around the time of surgery. Conclusions POISE-2 is a large international trial that will rigorously evaluate the effects of low-dose clonidine and ASA in patients having noncardiac surgery. Patients were also randomized to perioperative clonidine 0. 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